Respiratory issues often begin with silent, chronic inflammation. Cardamom supports respiratory health through its bronchodilatory, anti-inflammatory, and expectorant properties, helping ease symptoms of asthma, bronchitis, and cough. By relaxing airway muscles, reducing inflammation, and clearing mucus, it offers a natural approach to respiratory relief, supported by traditional use and promising animal studies.
Anti-inflammatory and cytotoxicity assay of Cardamom-based nutraceuticals in comparison with 1,8 -Cineol
Korambayil PM, Varkey P, Tharakan M. J. Drug Delivery Ther. [Internet]. 2023 Oct. 15 [cited 2025 Jul. 1];13(10):88-93.
This study evaluated the anti-inflammatory and cytotoxic effects of Recovereez® (51% 1,8-Cineole) and natural 1,8-Cineole using RAW 264.7 and L929 cell lines. Both compounds significantly reduced inflammatory markers including IL-6, TNF-α, iNOS, COX, LOX, NO, and MPO, with inhibition levels comparable to or better than diclofenac sodium. Cell viability assays showed 60% survival, indicating low cytotoxicity at effective anti-inflammatory doses. These results suggest that Recovereez® and 1,8-Cineole are safe, potent bioactive agents with potential for use in nutraceutical products targeting inflammation and possibly cancer prevention.
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This study evaluated the anti-inflammatory and cytotoxic effects of Recovereez® (51% 1,8-Cineole) and natural 1,8-Cineole using RAW 264.7 and L929 cell lines. Both compounds significantly reduced inflammatory markers including IL-6, TNF-α, iNOS, COX, LOX, NO, and MPO, with inhibition levels comparable to or better than diclofenac sodium. Cell viability assays showed 60% survival, indicating low cytotoxicity at effective anti-inflammatory doses. These results suggest that Recovereez® and 1,8-Cineole are safe, potent bioactive agents with potential for use in nutraceutical products targeting inflammation and possibly cancer prevention.
Advancements in Respiratory Health: Evaluation of the Therapeutic Potential of 1,8-Cineole from Chronic Conditions to COVID-19 Era
Dr. Austin Joju Akkara, Dr. Neha Shibu Elenjickal#b, Dr. Prashanth Varkeyc, Dr. Manjunatha P MudagalInt Neurourol J. 2023;27(4).
This study explores the potential of 1,8-cineole, a natural compound in cardamom, in treating respiratory diseases such as asthma, COPD, bronchitis, and COVID-19. It highlights how 1,8-cineole, used in the form of Recovereez Forte, reduces inflammation, improves lung function, and accelerates recovery. A unique aspect of the study is the use of saliva testing as a simple, non-invasive method to monitor inflammatory markers. Overall, the findings support 1,8-cineole as a promising bridge between traditional remedies and modern respiratory care, calling for more research to confirm its long-term benefits.
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This study explores the potential of 1,8-cineole, a natural compound in cardamom, in treating respiratory diseases such as asthma, COPD, bronchitis, and COVID-19. It highlights how 1,8-cineole, used in the form of Recovereez Forte, reduces inflammation, improves lung function, and accelerates recovery. A unique aspect of the study is the use of saliva testing as a simple, non-invasive method to monitor inflammatory markers. Overall, the findings support 1,8-cineole as a promising bridge between traditional remedies and modern respiratory care, calling for more research to confirm its long-term benefits.
A CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF RECOVEREEZ FORTE TM AS AN ADJUNCT TO COVID-19 TREATMENT
Varkey, Prashanth & Ajit, Amita & Hynse, Aimy & Kumar, Aparajita & Tharakan, Matthan. (2022). EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH. 9. 517-527.
This review highlights that while both asthma and COPD involve chronic inflammation of the airways, they are driven by distinct immune and inflammatory cell profiles. Asthma typically involves eosinophilic inflammation, whereas COPD is dominated by neutrophilic inflammation.
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This review highlights that while both asthma and COPD involve chronic inflammation of the airways, they are driven by distinct immune and inflammatory cell profiles. Asthma typically involves eosinophilic inflammation, whereas COPD is dominated by neutrophilic inflammation.
Immunology of asthma and chronic obstructive pulmonary disease
Peter J Barnes, Nat Rev Immunol. 2008 Mar;8(3):183-92. doi: 10.1038/nri2254. Epub 2008 Feb 15. PMID: 18274560.
This review highlights that while both asthma and COPD involve chronic inflammation of the airways, they are driven by distinct immune and inflammatory cell profiles. Asthma typically involves eosinophilic inflammation, whereas COPD is dominated by neutrophilic inflammation.
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This review highlights that while both asthma and COPD involve chronic inflammation of the airways, they are driven by distinct immune and inflammatory cell profiles. Asthma typically involves eosinophilic inflammation, whereas COPD is dominated by neutrophilic inflammation.
Pharmacological studies of cardamom oil in animals
H al-Zuhair 1, B el-Sayeh, H A Ameen, H al-Shoora, Pharmacol Res. 1996 Jul-Aug;34(1-2):79-82. doi: 10.1006/phrs.1996.0067. PMID: 8981560.
This study evaluated the pharmacological effects of cardamom seed oil, particularly its anti-inflammatory, analgesic, and antispasmodic properties. In animal models, the oil significantly reduced inflammation comparable to indomethacin and offered 50% protection against chemically induced pain in mice. Its antispasmodic effect was observed in rabbit intestines and was linked to muscarinic receptor blockade. These findings support cardamom oil’s potential as a natural remedy for inflammation, pain, and gastrointestinal spasms.
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This study evaluated the pharmacological effects of cardamom seed oil, particularly its anti-inflammatory, analgesic, and antispasmodic properties. In animal models, the oil significantly reduced inflammation comparable to indomethacin and offered 50% protection against chemically induced pain in mice. Its antispasmodic effect was observed in rabbit intestines and was linked to muscarinic receptor blockade. These findings support cardamom oil’s potential as a natural remedy for inflammation, pain, and gastrointestinal spasms.
Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial
U R Juergens 1, U Dethlefsen, G Steinkamp, A Gillissen, R Repges, H Vetter, Respir Med. 2003 Mar;97(3):250-6. doi: 10.1053/rmed.2003.1432. PMID: 12645832.
This clinical study evaluated the anti-inflammatory efficacy of 1,8-cineole (eucalyptol) in patients with severe steroid-dependent asthma. Over 12 weeks, patients treated with 1,8-cineole showed a 36% reduction in daily prednisolone dosage, significantly greater than the 7% reduction seen in the placebo group. The monoterpene effectively suppressed inflammatory mediators, demonstrating a steroid-sparing effect and improved asthma control. This provides the first clinical evidence of 1,8-cineole’s potential as an anti-inflammatory and mucolytic agent in airway diseases.
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This clinical study evaluated the anti-inflammatory efficacy of 1,8-cineole (eucalyptol) in patients with severe steroid-dependent asthma. Over 12 weeks, patients treated with 1,8-cineole showed a 36% reduction in daily prednisolone dosage, significantly greater than the 7% reduction seen in the placebo group. The monoterpene effectively suppressed inflammatory mediators, demonstrating a steroid-sparing effect and improved asthma control. This provides the first clinical evidence of 1,8-cineole’s potential as an anti-inflammatory and mucolytic agent in airway diseases.