Cardamom contains powerful natural compounds like cardamonin and alpinetin that have shown the ability to fight lung and breast cancer cells in lab studies by triggering cancer cell death and blocking pathways involved in tumor growth and spread.
Particularly in triple-negative breast cancer, cardamom’s bioactives may reduce metastasis and inflammation, offering potential as a supportive natural therapy, though human trials are still needed to confirm these benefits.
Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic.
Bano, S., Majumder, A., Srivastava, A., & Nayak, K. (2024). Biomolecules, 14. https://doi.org/10.3390/biom14091166.
This review highlights cardamom’s powerful antioxidant, anti-inflammatory, antimicrobial, and anti-diabetic properties, along with its emerging role in cancer prevention and therapy. Various phytochemicals extracted from cardamom—such as cardamonin, limonene, indole-3-carbinol, and diindolylmethane—have shown potential in targeting cancer cells by promoting programmed cell death and modulating key genetic pathways. Cardamom may also help overcome chemotherapy resistance and reduce its toxicity, making it a supportive agent during cancer treatment. While preclinical studies are promising, further clinical research is needed to validate cardamom’s effectiveness and safety in cancer care.
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This review highlights cardamom’s powerful antioxidant, anti-inflammatory, antimicrobial, and anti-diabetic properties, along with its emerging role in cancer prevention and therapy. Various phytochemicals extracted from cardamom—such as cardamonin, limonene, indole-3-carbinol, and diindolylmethane—have shown potential in targeting cancer cells by promoting programmed cell death and modulating key genetic pathways. Cardamom may also help overcome chemotherapy resistance and reduce its toxicity, making it a supportive agent during cancer treatment. While preclinical studies are promising, further clinical research is needed to validate cardamom’s effectiveness and safety in cancer care.
Immunostimulant/Cytotoxic Effect of Cardamom Extract with Adjuvant Combination on Breast Cancer Cell Line.
Zengin, Y., Ihlamur, M., & Başari, H. (2022). Bayburt Üniversitesi Fen Bilimleri Dergisi. https://doi.org/10.55117/bufbd.1144102.
This study explored how cardamom extract, a natural compound from the Elettaria cardamomum plant, could help prevent or treat breast cancer. Two key molecules in cardamom, diindolylmethane (DIM) and indole-3-carbinol (I3C), have already been shown to fight cancer by triggering cell death in cancer cells and reducing the spread of tumors. Researchers tested cardamom extract alone and in combination with Freund’s adjuvant (a booster) on breast cancer cells and immune cells in the lab. They found that the combination was more effective than cardamom alone, and increasing the cardamom dose helped reduce the harmful effects of the adjuvant, making the treatment potentially safer and more powerful.
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This study explored how cardamom extract, a natural compound from the Elettaria cardamomum plant, could help prevent or treat breast cancer. Two key molecules in cardamom, diindolylmethane (DIM) and indole-3-carbinol (I3C), have already been shown to fight cancer by triggering cell death in cancer cells and reducing the spread of tumors. Researchers tested cardamom extract alone and in combination with Freund’s adjuvant (a booster) on breast cancer cells and immune cells in the lab. They found that the combination was more effective than cardamom alone, and increasing the cardamom dose helped reduce the harmful effects of the adjuvant, making the treatment potentially safer and more powerful.
Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells.
Rodenak-Kladniew, B., Castro, M., Crespo, R., Galle, M., & De Bravo, G. (2020). Heliyon, 6. https://doi.org/10.1016/j.heliyon.2020.e05639.
This study explored how two natural plant compounds, linalool and 1,8-cineole, affect lung adenocarcinoma (A549) cells. Both compounds were found to slow cancer cell growth by arresting the cell cycle, without harming normal lung cells. Linalool increased oxidative stress and disrupted mitochondrial function, while both compounds also inhibited cancer cell migration. Additionally, when combined with the drug simvastatin, they enhanced cell cycle arrest and made cancer cells more sensitive to treatment, showing potential as supportive agents in lung cancer therapy.
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This study explored how two natural plant compounds, linalool and 1,8-cineole, affect lung adenocarcinoma (A549) cells. Both compounds were found to slow cancer cell growth by arresting the cell cycle, without harming normal lung cells. Linalool increased oxidative stress and disrupted mitochondrial function, while both compounds also inhibited cancer cell migration. Additionally, when combined with the drug simvastatin, they enhanced cell cycle arrest and made cancer cells more sensitive to treatment, showing potential as supportive agents in lung cancer therapy.
Potential action of cardamom (Elettaria cardamomum) against triple-negative breast cancer.
Samanta, A., Dobhal, K., Singh, A., Verma, S., & Jakhmola, V. (2023). BLDE University Journal of Health Sciences, 8, 210 – 219. https://doi.org/10.4103/bjhs.bjhs_36_23.
Triple-negative breast cancer (TNBC) is a highly aggressive and hard-to-treat form of breast cancer that lacks the usual hormone receptors targeted by common therapies. Researchers have found that natural compounds in cardamom—especially cardamonin—may offer hope by attacking cancer cells through specific pathways and triggering cell death without harming healthy cells. Cardamonin and its metal-enhanced forms show improved effectiveness and absorption in cancer cells, making them a potential natural weapon against TNBC. This review suggests that cardamom could be developed into a safe and effective treatment option for TNBC, offering new possibilities for patients who currently have limited choices.
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Triple-negative breast cancer (TNBC) is a highly aggressive and hard-to-treat form of breast cancer that lacks the usual hormone receptors targeted by common therapies. Researchers have found that natural compounds in cardamom—especially cardamonin—may offer hope by attacking cancer cells through specific pathways and triggering cell death without harming healthy cells. Cardamonin and its metal-enhanced forms show improved effectiveness and absorption in cancer cells, making them a potential natural weapon against TNBC. This review suggests that cardamom could be developed into a safe and effective treatment option for TNBC, offering new possibilities for patients who currently have limited choices.
Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway.
Zhou, X., Zhou, R., Li, Q., Jie, X., Hong, J., Zong, Y., Dong, X., Zhang, S., Li, Z., & Wu, G. (2019). Anti-Cancer Drugs, 30, 241–250. https://doi.org/10.1097/CAD.0000000000000709.
Cardamonin, a natural compound found in cardamom, was tested for its ability to fight non-small-cell lung cancer (NSCLC), the most common type of lung cancer. In lab and animal studies, cardamonin stopped cancer cells from growing, made them self-destruct, and blocked their ability to spread by interfering with important proteins that help cancer grow and survive. It also slowed tumor growth in mice and reduced markers linked to cancer progression. These results suggest that cardamonin may be a promising natural treatment option for lung cancer in the future.
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Cardamonin, a natural compound found in cardamom, was tested for its ability to fight non-small-cell lung cancer (NSCLC), the most common type of lung cancer. In lab and animal studies, cardamonin stopped cancer cells from growing, made them self-destruct, and blocked their ability to spread by interfering with important proteins that help cancer grow and survive. It also slowed tumor growth in mice and reduced markers linked to cancer progression. These results suggest that cardamonin may be a promising natural treatment option for lung cancer in the future.
