Cardamom essential oil has demonstrated neuroprotective and antioxidant effects in animal studies, reducing oxidative stress, enhancing brain antioxidant enzymes, and lowering acetylcholinesterase levels linked to Alzheimer’s disease.
It also improved behavioral symptoms in depression models, suggesting its potential to support cognitive function and emotional well-being.
Amelioration of DENA-induced oxidative stress in rat kidney and brain by the essential oil of Elettaria cardamomum.
Elguindy, N., Yacout, G., & Azab, E. (2018). Beni-Suef University Journal of Basic and Applied Sciences. https://doi.org/10.1016/J.BJBAS.2018.02.005.
This study evaluated the protective effects of cardamom essential oil and geraniol against diethylnitrosamine (DENA)-induced oxidative stress in the brain and kidneys of rats. Both treatments significantly reduced markers of oxidative damage, including lipid peroxidation, while increasing glutathione levels and antioxidant enzyme activities such as catalase, SOD, GPx, GR, and GST. They also lowered the activity of ornithine decarboxylase (ODC) and acetylcholinesterase (AChE), enzymes linked to cancer progression and neurotoxicity, respectively. These findings suggest that cardamom essential oil possesses potent antioxidant, neuroprotective, and chemopreventive properties.
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This study evaluated the protective effects of cardamom essential oil and geraniol against diethylnitrosamine (DENA)-induced oxidative stress in the brain and kidneys of rats. Both treatments significantly reduced markers of oxidative damage, including lipid peroxidation, while increasing glutathione levels and antioxidant enzyme activities such as catalase, SOD, GPx, GR, and GST. They also lowered the activity of ornithine decarboxylase (ODC) and acetylcholinesterase (AChE), enzymes linked to cancer progression and neurotoxicity, respectively. These findings suggest that cardamom essential oil possesses potent antioxidant, neuroprotective, and chemopreventive properties.
Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats.
Auti, S., & Kulkarni, Y. (2019). Frontiers in Neurology, 10. https://doi.org/10.3389/fneur.2019.00399.
This study investigated the neuroprotective potential of cardamom oil in a rat model of Alzheimer’s disease induced by aluminum chloride. Cardamom oil significantly improved memory and behavior, inhibited acetylcholinesterase activity, and reduced oxidative stress in the brain. It also decreased amyloid β plaque formation and neuronal damage while increasing brain-derived neurotrophic factor (BDNF) levels. These findings suggest that cardamom oil may offer therapeutic benefits in managing Alzheimer’s disease through antioxidant and cholinesterase-inhibitory mechanisms.
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This study investigated the neuroprotective potential of cardamom oil in a rat model of Alzheimer’s disease induced by aluminum chloride. Cardamom oil significantly improved memory and behavior, inhibited acetylcholinesterase activity, and reduced oxidative stress in the brain. It also decreased amyloid β plaque formation and neuronal damage while increasing brain-derived neurotrophic factor (BDNF) levels. These findings suggest that cardamom oil may offer therapeutic benefits in managing Alzheimer’s disease through antioxidant and cholinesterase-inhibitory mechanisms.
Cardamom oil ameliorates behavioral and neuropathological disorders in a rat model of depression induced by reserpine
Abdel-Rasoul, A., Saleh, N., Hosny, E., El-Gizawy, M., & Ibrahim, E. (2023). Journal of ethnopharmacology, 116254 . https://doi.org/10.1016/j.jep.2023.116254.
This study evaluated the antidepressant potential of cardamom oil in a rat model of reserpine-induced depression. Cardamom oil improved depressive behaviors and restored brain neurotransmitter levels, reduced oxidative and nitrosative stress, and enhanced antioxidant defenses. It also inhibited monoamine oxidase activity and increased levels of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus. These findings suggest that cardamom oil may serve as a safe and effective natural alternative or adjunct for managing depression.
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This study evaluated the antidepressant potential of cardamom oil in a rat model of reserpine-induced depression. Cardamom oil improved depressive behaviors and restored brain neurotransmitter levels, reduced oxidative and nitrosative stress, and enhanced antioxidant defenses. It also inhibited monoamine oxidase activity and increased levels of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus. These findings suggest that cardamom oil may serve as a safe and effective natural alternative or adjunct for managing depression.
