Cardamom, rich in polyphenols and bioactive compounds, supports metabolic health by reducing diastolic blood pressure, triglycerides, total cholesterol, and key inflammatory markers such as hs-CRP and IL-6.
Both clinical and animal studies suggest that cardamom improves insulin resistance, glucose tolerance, and liver function, indicating its potential as a functional food in managing metabolic syndrome and related disorders.
Effect of cardamom supplementation on a number of metabolic factors: A systematic review and meta-analysis
Nameni G, Moradi Y, Zaroudi M, Jamshidi S. Diabetes Metab Syndr. 2022 Jun;16(6):102523. doi: 10.1016/j.dsx.2022.102523. Epub 2022 May 25. PMID: 35691204.
This meta-analysis of six randomized controlled trials involving 410 participants evaluated the effect of cardamom supplementation on glycemic indices and weight profile. While cardamom had no significant impact on body weight, BMI, waist circumference, fasting blood sugar, or insulin levels, it significantly improved HOMA-IR and HbA1c levels, indicating better insulin sensitivity and long-term glucose control. These findings suggest that cardamom may help regulate glucose metabolism even if it doesn’t alter anthropometric measures. Thus, cardamom shows promise as a supportive nutraceutical for improving glycemic control in clinical settings.
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This meta-analysis of six randomized controlled trials involving 410 participants evaluated the effect of cardamom supplementation on glycemic indices and weight profile. While cardamom had no significant impact on body weight, BMI, waist circumference, fasting blood sugar, or insulin levels, it significantly improved HOMA-IR and HbA1c levels, indicating better insulin sensitivity and long-term glucose control. These findings suggest that cardamom may help regulate glucose metabolism even if it doesn’t alter anthropometric measures. Thus, cardamom shows promise as a supportive nutraceutical for improving glycemic control in clinical settings.
Effect of cardamom consumption on inflammation and blood pressure in adults: A systematic review and meta-analysis of randomized clinical trials
Heydarian A, Tahvilian N, Shahinfar H, Abbas-Hashemi SA, Daryabeygi-Khotbehsara R, Aryaeian N. Food Sci Nutr. 2023 Oct 7;12(1):3-12. doi: 10.1002/fsn3.3738. PMID: 38268891; PMCID: PMC10804083.
This systematic review and meta-analysis assessed the anti-inflammatory and antihypertensive effects of cardamom based on eight clinical trials. The findings revealed that cardamom significantly reduced inflammatory markers such as hs-CRP, IL-6, and TNF-α, along with modest but significant decreases in both systolic and diastolic blood pressure. These results support cardamom’s potential as a natural therapeutic agent for managing inflammation and hypertension. However, the limited number of included studies highlights the need for further large-scale, high-quality clinical trials to confirm these effects.
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This systematic review and meta-analysis assessed the anti-inflammatory and antihypertensive effects of cardamom based on eight clinical trials. The findings revealed that cardamom significantly reduced inflammatory markers such as hs-CRP, IL-6, and TNF-α, along with modest but significant decreases in both systolic and diastolic blood pressure. These results support cardamom’s potential as a natural therapeutic agent for managing inflammation and hypertension. However, the limited number of included studies highlights the need for further large-scale, high-quality clinical trials to confirm these effects.
The effect of green cardamom on blood pressure and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials
Izadi B, Joulaei H, Lankarani KB, Tabrizi R, Taherifard E, Sadeghpour A, Vali M, Akbari
M. Phytother Res. 2023 Feb;37(2):679-688. doi: 10.1002/ptr.7648. Epub 2022 Sep 30. PMID: 36181264.
This systematic review and meta-analysis evaluated the effects of green cardamom on metabolic syndrome and related disorders. Analyzing data from eight clinical trials with 595 patients, it found that cardamom significantly reduced diastolic blood pressure, hs-CRP, and IL-6 levels, indicating anti-inflammatory and blood pressure-lowering effects. However, no significant effect was observed on systolic blood pressure. While the results are promising, the small number of trials and limited sample sizes highlight the need for further large-scale studies.
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This systematic review and meta-analysis evaluated the effects of green cardamom on metabolic syndrome and related disorders. Analyzing data from eight clinical trials with 595 patients, it found that cardamom significantly reduced diastolic blood pressure, hs-CRP, and IL-6 levels, indicating anti-inflammatory and blood pressure-lowering effects. However, no significant effect was observed on systolic blood pressure. While the results are promising, the small number of trials and limited sample sizes highlight the need for further large-scale studies.
Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial
Daneshi-Maskooni M, Keshavarz SA, Qorbani M, Mansouri S, Alavian SM, Badri-Fariman M, Jazayeri-Tehrani SA, Sotoudeh G. Nutr Metab (Lond). 2018 Sep 25;15:63. doi: 10.1186/s12986-018-0297-4. PMID: 30263038; PMCID: PMC6156864.
This human clinical trial investigated the effects of green cardamom supplementation on inflammatory markers, liver enzymes, and Sirtuin-1 levels in overweight or obese patients with non-alcoholic fatty liver disease (NAFLD). After 3 months of supplementation, green cardamom significantly increased Sirt1 and reduced hs-CRP, TNF-α, IL-6, ALT, and the degree of fatty liver compared to placebo. However, no significant changes were observed in AST, weight, or BMI. These findings suggest that green cardamom may offer therapeutic benefits in managing inflammation and liver health in NAFLD patients.
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This human clinical trial investigated the effects of green cardamom supplementation on inflammatory markers, liver enzymes, and Sirtuin-1 levels in overweight or obese patients with non-alcoholic fatty liver disease (NAFLD). After 3 months of supplementation, green cardamom significantly increased Sirt1 and reduced hs-CRP, TNF-α, IL-6, ALT, and the degree of fatty liver compared to placebo. However, no significant changes were observed in AST, weight, or BMI. These findings suggest that green cardamom may offer therapeutic benefits in managing inflammation and liver health in NAFLD patients.
Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats.
Rahman MM, Alam MN, Ulla A, Sumi FA, Subhan N, Khan T, Sikder B, Hossain H, Reza HM, Alam MA. Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats. Lipids Health Dis. 2017 Aug 14;16(1):151. doi:
10.1186/s12944-017-0539-x. PMID: 28806968; PMCID: PMC5557534.
This animal study evaluated the protective effects of cardamom powder supplementation in rats fed a high carbohydrate high fat (HCHF) diet. The results showed that cardamom significantly improved glucose intolerance, reduced abdominal fat deposition, and prevented dyslipidemia and liver inflammation caused by the HCHF diet. It also normalized elevated liver enzymes (ALT, AST, ALP), reduced oxidative stress, and prevented hepatic fibrosis. These findings suggest that cardamom powder can mitigate diet-induced metabolic disturbances and liver damage.
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This animal study evaluated the protective effects of cardamom powder supplementation in rats fed a high carbohydrate high fat (HCHF) diet. The results showed that cardamom significantly improved glucose intolerance, reduced abdominal fat deposition, and prevented dyslipidemia and liver inflammation caused by the HCHF diet. It also normalized elevated liver enzymes (ALT, AST, ALP), reduced oxidative stress, and prevented hepatic fibrosis. These findings suggest that cardamom powder can mitigate diet-induced metabolic disturbances and liver damage.
Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial.
Kazemi S, Yaghooblou F, Siassi F, Rahimi Foroushani A, Ghavipour M, Koohdani F, Sotoudeh G. J Sci Food Agric. 2017 Dec;97(15):5296-5301. doi: 10.1002/jsfa.8414. Epub 2017 Jul 17. PMID: 28480505.
This randomized, double-blind, placebo-controlled clinical trial evaluated the effects of cardamom supplementation (3 g/day for 8 weeks) on inflammation and oxidative stress in overweight and obese pre-diabetic women. The study found that cardamom significantly reduced serum levels of hs-CRP, the hs-CRP:IL-6 ratio, and malondialdehyde (MDA), a marker of lipid peroxidation. These improvements indicate a reduction in systemic inflammation and oxidative stress. The findings suggest that cardamom may be beneficial in managing early metabolic disturbances in pre-diabetic individuals.
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This randomized, double-blind, placebo-controlled clinical trial evaluated the effects of cardamom supplementation (3 g/day for 8 weeks) on inflammation and oxidative stress in overweight and obese pre-diabetic women. The study found that cardamom significantly reduced serum levels of hs-CRP, the hs-CRP:IL-6 ratio, and malondialdehyde (MDA), a marker of lipid peroxidation. These improvements indicate a reduction in systemic inflammation and oxidative stress. The findings suggest that cardamom may be beneficial in managing early metabolic disturbances in pre-diabetic individuals.
