Cardamom and Heart Health: Natural Support Against Inflammation - Zum Heilen: One Health

Natural Heart Health and Inflammation Support

Cardamom for Cardiac Wellness

Cardamom’s antioxidative and anti-inflammatory properties help support heart health by reducing oxidative stress and inflammation, contributing to natural cardiovascular wellness.

Overview

Cardamom supports heart health through its antioxidant, anti-inflammatory, and lipid-lowering properties, helping to reduce key cardiovascular risk markers like triglycerides, CRP, IL-6, and TNF-α.

It may also aid in lowering blood pressure and protecting heart muscle cells from stress-induced damage.

Research & Publications

Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats

Goyal SN, Sharma C, Mahajan UB, Patil CR, Agrawal YO, Kumari S, Arya DS, Ojha S. Int J Mol Sci. 2015 Nov 17;16(11):27457-69. doi: 10.3390/ijms161126040. PMID: 26593900; PMCID: PMC4661898.

This study investigated the cardioprotective effects of cardamom in rats with isoproterenol-induced myocardial infarction. Cardamom pretreatment improved heart function, stabilized blood pressure, and reduced heart rate abnormalities caused by cardiac injury. It restored antioxidant enzyme levels, reduced lipid peroxidation, and preserved cardiac muscle enzyme activity. Histopathological and ultrastructural analyses confirmed that cardamom protected heart tissue by counteracting oxidative stress and cellular damage.

Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial

Kazemi S, Yaghooblou F, Siassi F, Rahimi Foroushani A, Ghavipour M, Koohdani F, Sotoudeh G. J Sci Food Agric. 2017 Dec;97(15):5296-5301. doi: 10.1002/jsfa.8414. Epub 2017 Jul 17. PMID: 28480505.

This randomized, double-blind clinical trial investigated the effects of cardamom supplementation in overweight and obese pre-diabetic women. After 8 weeks of consuming 3 g/day of cardamom, participants showed significant reductions in inflammatory markers like hs-CRP and oxidative stress marker MDA compared to the placebo group. The study also noted improvement in the hs-CRP:IL-6 ratio, indicating a favorable anti-inflammatory effect. These results suggest that cardamom may help mitigate inflammation and oxidative stress in pre-diabetic individuals.

The effect of green cardamom on blood pressure and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials

Izadi B, Joulaei H, Lankarani KB, Tabrizi R, Taherifard E, Sadeghpour A, Vali M, Akbari M. Phytother Res. 2023 Feb;37(2):679-688. doi: 10.1002/ptr.7648. Epub 2022 Sep 30. PMID: 36181264.

This systematic review and meta-analysis evaluated the effects of green cardamom on metabolic syndrome and related disorders. Analyzing data from eight clinical trials with 595 patients, it found that cardamom significantly reduced diastolic blood pressure, hs-CRP, and IL-6 levels, indicating anti-inflammatory and blood pressure-lowering effects. However, no significant effect was observed on systolic blood pressure. While the results are promising, the small number of trials and limited sample sizes highlight the need for further large-scale studies.

Cardamom consumption may improve cardiovascular metabolic biomarkers in adults: A systematic review and meta-analysis of randomized controlled trials

Zhang X, Wang C, Min R, Zhou Q, Qi Y, Fan J. Nutr Res. 2024 May;125:101-112. doi: 10.1016/j.nutres.2024.03.002. Epub 2024 Mar 12. PMID: 38593657

This meta-analysis of 12 clinical trials involving 989 participants assessed the effects of cardamom on cardiovascular metabolic biomarkers. The results showed that cardamom significantly reduced total cholesterol, triglycerides, hs-CRP, and IL-6, indicating improvements in lipid profile and inflammation. However, it had no significant effect on HDL, LDL, or certain oxidative stress markers. These findings support cardamom’s potential role in promoting cardiovascular health, though further large, well-designed clinical trials are needed for stronger evidence.

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