Cardamom and Liver Health: Natural Support Against Inflammation - Zum Heilen: One Health

Natural Liver Support and Inflammation Care

Cardamom for Liver Health

Cardamom’s antioxidative and anti-inflammatory properties help protect the liver from oxidative stress, supporting natural detoxification and liver wellness.

Overview

Cardamom has demonstrated protective effects on liver health by reducing inflammation, oxidative stress, and fat accumulation in both animal and human studies, particularly in conditions like NAFLD and drug-induced liver injury.

These benefits are linked to its rich polyphenol and flavonoid content, which enhance antioxidant defenses and modulate metabolic and cellular pathways critical to liver function.

Research & Publications

Cardamom Extract Alleviates the Oxidative Stress, Inflammation and Apoptosis Induced during Acetaminophen-Induced Hepatic Toxicity via Modulating Nrf2/HO-1/NQO-1 Pathway

Alkhalifah EAR, Alobaid AA, Almajed MA, Alomair MK, Alabduladheem LS, Al-Subaie SF, Akbar A, Attimarad MV, Younis NS, Mohamed ME. Curr Issues Mol Biol. 2022 Nov 2;44(11):5390-5404. doi: 10.3390/cimb44110365. PMID: 36354677; PMCID: PMC9688982.

This study evaluated the hepatoprotective effect of cardamom (CARD) aqueous extract against acetaminophen (APAP)-induced liver toxicity in mice. Chemical profiling revealed the presence of polyphenols, flavonoids, cinnamic acid derivatives, and essential oil components in the extract. Pretreatment with CARD significantly reduced liver damage markers, oxidative stress, inflammation, and apoptosis, while enhancing antioxidant enzyme activity and upregulating the Nrf2/HO-1/NQO-1 pathway. The findings suggest that cardamom extract may offer protection against acute liver injury through its antioxidant and anti-inflammatory mechanisms.

Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial

Daneshi-Maskooni M, Keshavarz SA, Qorbani M, Mansouri S, Alavian SM, Badri-Fariman M, Jazayeri-Tehrani SA, Sotoudeh G. Nutr Metab (Lond). 2018 Sep 25;15:63. doi: 10.1186/s12986-018-0297-4. PMID: 30263038; PMCID: PMC6156864.

This clinical study investigated the effects of green cardamom supplementation in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD). Over a 3-month period, cardamom significantly increased Sirtuin-1 levels and decreased inflammatory markers (hs-CRP, TNF-α, IL-6), alanine transaminase (ALT), and liver fat grade compared to placebo. However, no significant changes were observed in AST, body weight, or BMI. The results suggest that green cardamom may offer anti-inflammatory and hepatoprotective benefits in NAFLD patients, warranting further research.

Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats

Rahman MM, Alam MN, Ulla A, Sumi FA, Subhan N, Khan T, Sikder B, Hossain H, Reza HM, Alam MA. Lipids Health Dis. 2017 Aug 14;16(1):151. doi: 10.1186/s12944-017-0539-x. PMID: 28806968; PMCID: PMC5557534.

This study evaluated the effects of cardamom powder supplementation in rats fed a high carbohydrate high fat (HCHF) diet to induce obesity and metabolic disturbances. Cardamom significantly improved glucose intolerance, reduced abdominal fat deposition, and normalized lipid profiles in HCHF-fed rats. It also reduced oxidative stress, normalized liver enzyme levels (ALT, AST, ALP), and decreased liver inflammation and fibrosis. These findings suggest that cardamom powder supplementation offers protective effects against dyslipidemia, hepatic injury, and oxidative stress in diet-induced obese models.

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